http://10.9.150.37:8080/dspace//handle/atmiyauni/1433 2026-04-27T18:57:52Z 2026-04-27T18:57:52Z Kadivar, Richa Joshi, Rachana http://10.9.150.37:8080/dspace//handle/atmiyauni/2286 2025-01-10T11:09:19Z 2024-11-01T00:00:00Z

Title: Formulation and Evaluation of Clindamycin Phosphate Microsponge Gel for Topical Drug Delivery Authors: Kadivar, Richa; Joshi, Rachana Abstract: Clindamycin is a potent lincosamide antibiotic against susceptible anaerobic bacteria and gram-positive aerobes. Furthermore, CLN also has anti-inflammatory activities. It is applied topically in the management of acne vulgaris.The current research was focused on gel loaded for the topical delivery to Clindamycin phosphate to overcome short half life problem of the drug and to minimize the side effects of drug with conventional gel. The FTIR study revealed that there was no interaction between drug and polymer and the combination is suitable for preparation of microsponges. Clindamycin phosphate loaded microsponges were prepared by oil in oil emulsion solvent diffusion method as the drug is highly water soluble and belongs to BCS class III. The microsponges were prepared by using ethyl cellulose as the polymer and incorporated into carbopol gel. The microsponges were evaluated for visual inspection, % yield, % drug content, % entrapement efficiency and particle size. The effect of formulation variables like stirring speed and drug:polymer ratio were evaluated on microsponges. The optimized formulation with drug:polymer ratio of 1:1, stirring speed of 1000rpm had the drug content of 78.69% and percent entrapement efficiency was found to be 87.94% The results concluded that as the drug:polymer ratio increases, drug content and entrapement efficiency decreases. The particle size of optimized batch of microsponges was found to be 37.44μm. The results of particle size analysis concluded that as the drug:polymer ratio increases, particle size increases. The microsponges of batch CLPA1-CLPA9 were subjected to in-vito drug release study by Franz diffusion cell apparatus. The batch showed the controlled release of 95.49% of drug release at 10 hrs. The results of in-vitro drug release showed that as the drug:polymer ratio increases, more controlled release formulation is obtained. The microsponges were incorporated into carbopol gel was evaluated for visual inspection, pH, spreadability and stability of gel at room temperature for 1 month. The transparent white microsponge gel had the pH of 6.38 with spreadability of 7.05 g cm/s. The gel was found to be stable after 1 month. In-vitro antibacterial activity was observed for microsponge gel and compared with marketed 1%w/w CLP gel (Clindac A).

2024-11-01T00:00:00Z Sheikh, Mohammed Farhan M. Ughreja, Reena http://10.9.150.37:8080/dspace//handle/atmiyauni/1434 2024-09-27T06:03:45Z 2024-07-16T00:00:00Z

Title: Solubility Enhancement Of Poorly Soluble Drugs By Formulation Of Solid Dispersion Using Soluplus® As A Carrier Authors: Sheikh, Mohammed Farhan M.; Ughreja, Reena Abstract: Treatment of tuberculosis makes great use of rifampicin. While Abiraterone Acetate is generally used for the treatment of prostate cancer, Duloxetine Hydrochloride is advised for the treatment of major depressive disorder. Still, the low water solubility of all these drugs affects their bioavailability. Thus, this work sought to generate solid dispersions thereby enhancing the solubility and hence the dissolution rate of Rifampicin, Duloxetine hydrochloride, and Abiraterone Acetate. Soluplus® was used as a carrier to enhance solubility; phase solubility investigations carried out in preliminary trials helped to ascertain the ratio. First investigations were carried out to select the suitable solvent and techniques; thereafter, solid dispersions were developed. The Physical characterization was done by DSC and FT-IR. DSC was performed to determine the thermal characteristics of the drug and FT-IR was performed to determine the compatibility between the drug and polymer. Melt and solvent evaporation techniques were used to produce the solid dispersion. The batches had ratios ranging from 1:1, 1:2, and 1:3. %Drug content, %yield, solubility studies, and in-vitro dissolution studies were among the evaluation parameters performed for the solid dispersion assessment. The batch showing good results was selected for further investigation with XRD, DSC, and FT-IR methods. The best batches of all the drugs (Rifampicin, Duloxetine HCL and Abiraterone Acetate) showed enhancement in the solubility and dissolution rate.

2024-07-16T00:00:00Z