http://10.9.150.37:8080/dspace//handle/atmiyauni/254 2026-04-27T19:00:15Z 2026-04-27T19:00:15Z Akbari, P.M Shah, V.R. http://10.9.150.37:8080/dspace//handle/atmiyauni/2205 2025-01-01T11:26:08Z 2019-01-01T00:00:00Z

Title: Synthesis, Characterization and Biological Evaluation of Ethyl-4'-(cyclopropane carboxamido-N-yl)-5-ary-3-oxo-3,4,5,6- tetrahydro-biphenyl-4-carboxylate Authors: Akbari, P.M; Shah, V.R. Abstract: A series of new substituted cyclohexenone derivatives have been synthesized by the reaction of various substituted chalcones with ethylacetoacetate. Some new N-(4-(3-aryl-acryloyl)phenyl)cyclopropane carboxamide were prepared by Claisen-Schmidt condensation method in presence of sodium hydroxide in ethanol solvent under stirring. The synthesized compounds were characterized by their spectral (IR, NMR, Mass) data and screened for their antimicrobial activities against Gram-positive and Gram-negative bacteria by using standard antimicrobial drugs.

2019-01-01T00:00:00Z Sanghani, Yogesh J. Koradiya, Suresh B. Jilariya, Krushnakumar J. http://10.9.150.37:8080/dspace//handle/atmiyauni/2194 2025-01-01T10:58:27Z 2020-01-01T00:00:00Z

Title: Synthesis, Characterization and in vitro Antimicrobial Evaluation of Pyrazole Based Oxothiazolidine Hybrids Authors: Sanghani, Yogesh J.; Koradiya, Suresh B.; Jilariya, Krushnakumar J. Abstract: In this work, pyrazole based oxothiazolidine hybrids, 4-{4-[2-(1- phenyl-3-(substituted)phenyl-1H-pyrazol-4-yl)-4-oxo-thiazolidin-3- yl]-phenyl}-morpholin-3-one (11a-l) were synthesized using molecular hybridization approach through Vilsmeier-Haack reaction. The titled compounds 11a-l were characterized by using elemental analysis, IR, 1H NMR and mass spectral studies. The antibacterial activity of 11a-l was evaluated in vitro by agar cup plate method against B. cocous, B. subtillis, E. coli and P. vulgaris. The antifungal activity of compounds 11a-l was evaluated in vitro by agar based disk diffusion method against A. niger. The results of antibacterial and antifungal evaluation were reported in terms of zone of inhibition measured in mm. The synthesized compounds 11a-l exhibited moderate to good antibacterial and antifungal potential. Compound 4-{4-[2-(1-phenyl-3-(2-methoxyphenyl) phenyl-1H-pyrazol-4-yl)-4-oxo-thiazolidin-3-yl]-phenyl}- morpholin-3-one (11h) emerged as a most potent antimicrobial agent displaying zone of inhibition 21, 20, 21, 24 and 20 mm against B. cocous, B. subtillis, E. coli, P. vulgaris and A. niger, respectively.

2020-01-01T00:00:00Z Devmurari, Vishvraj V. Patel, Poojaben P. Jadeja, Rajeshreeba A. Bhadaniya, Cameykumari P. Aghara, Priti P. Patel, Anilkumar S. Tala, Satishkumar D. Savant, Mahesh M. Ladva, Kartik D. Nariya, Pankajkumar B. http://10.9.150.37:8080/dspace//handle/atmiyauni/990 2023-05-17T05:07:47Z 2021-06-30T00:00:00Z

Title: Steroid and fatty acid contents from the leaves of Carica Papaya Authors: Devmurari, Vishvraj V.; Patel, Poojaben P.; Jadeja, Rajeshreeba A.; Bhadaniya, Cameykumari P.; Aghara, Priti P.; Patel, Anilkumar S.; Tala, Satishkumar D.; Savant, Mahesh M.; Ladva, Kartik D.; Nariya, Pankajkumar B. Abstract: Aim: To extract and identify the non-polar entities from the leaves of Carica papaya, a plant used for medicinal purpose as folk medicine. Materials and methods: Petroleum ether extract of the Carica papaya leaves was used for this study. Saponification process and methylation process was performed to separate fatty acids and unsaponifiable matters. Phytochemical constituents were separated using chemical process and separated fractions were analyzed by thin layer chromatography (TLC) and gas chromatography coupled with mass spectroscopy (GC-MS). Results: The chemical composition of the steroids, triterpenoids and fatty acid methyl esters (FAMEs) in leaves of Carica papaya, which were analyzed by gas chromatography coupled with mass spectroscopy (GC-MS). A total of 15 fatty acid components were identified in saponifiable matter, from unsaponifiable portion 2 steroids (campesterol, β- or γ-sitosterol), 1 triterpene (squalene), and 1 diterpene (phytol) were identified. Conclusions: The results indicate that the extract is rich in non-polar compounds. In this study, GC-MS method is at the central focus for identification of these phytoconstituents. The current method can be used for direct analysis of non-polar entities of plant material. Description: We are grateful to the Department of Chemistry, Atmiya University and Shri M. & N. Virani Science College, Rajkot for providing laboratory and other required facilities.

2021-06-30T00:00:00Z Desai, Rajesh Koradiya, Suresh http://10.9.150.37:8080/dspace//handle/atmiyauni/870 2023-05-08T04:33:59Z 2019-01-01T00:00:00Z

Title: Isolation, identification and characterization of degradation impurity of atorvastatin in fixed dose combination of atorvastatin and ezetimibe Authors: Desai, Rajesh; Koradiya, Suresh Abstract: The objective of this study is to isolation and characterization of unknown degradation product of Atorvastatin calcium in combination formulation product with Ezetimibe by using modern techniques of separation and characterization. An unknown impurity is generating during a forced degradation study of Atorvastatin and Ezetimibe fixed-dose combination tablets. By using the gradient reversed-phase high-pressure liquid chromatographic method, unknown degradation impurity was detected and quantified in the range of 0.05% to 0.2% of Atorvastatin. The impurity was enriched by extreme oxidation degradation of Atorvastatin and isolated through preparative HPLC. The structure of the impurity was characterized by mass and NMR spectrum.

2019-01-01T00:00:00Z