http://10.9.150.37:8080/dspace//handle/atmiyauni/488 Mon, 27 Apr 2026 18:51:06 GMT 2026-04-27T18:51:06Z http://10.9.150.37:8080/dspace//handle/atmiyauni/2273 Title: Formulation of Diacerein Cocrystal Using β‑Resorcylic Acid for Improvement of Physicomechanical and Biopharmaceutical Properties Authors: Patel, Rajeshri D.; Raval, Mihir K. Abstract: Diacerein (DIA) is an approved treatment for osteoarthritis. However, its clinical effectiveness is limited because of its poor aqueous solubility, which causes bioavailability issues. The current study aimed to augment the functionality of DIA using a cocrystallization approach. A newly developed cocrystal of DIA with β-resorcylic acid (RA) was produced at different ratios via the antisolvent crystallization technique. Differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), Fourier transform IR (FT-IR) spectroscopy, and scanning electron microscopy (SEM) were carried out to investigate the formation of the cocrystals. The cocrystallized samples were further evaluated for their biopharmaceutical properties. The DSC study demonstrated a “W”-type phase diagram with a sharp endothermic event at a DIA:RA molar ratio of 1:3. A distinct PXRD pattern at the optimized ratio confirmed the formation of a novel cocrystal, and this was confirmed using FT-IR analysis. SEM analysis revealed the topographical variation of the prepared cocrystal, suggesting the generation of a new solid phase. Physicomechanical properties such as apparent solubility, dissolution, packability, compressibility, compactibility, and stability exhibited the improved functionality of the prepared cocrystal compared with pure DIA. Significant enhancement of bioavailability (3.2-fold) was observed for the prepared cocrystal relative to DIA alone. Hence, the fast dissolving capability and improved tabletability and bioavailability of the DIA−RA cocrystal make it a more favorable candidate for better dosage form development Fri, 01 Jan 2021 00:00:00 GMT http://10.9.150.37:8080/dspace//handle/atmiyauni/2273 2021-01-01T00:00:00Z http://10.9.150.37:8080/dspace//handle/atmiyauni/2264 Title: Gas chromatographic–mass spectrometric profile of non-polar fraction and high-performance thin-layer chromatographic analysis of methanolic fraction with simultaneous quantifications of protocatechuic acid and quercetin in Carissa carandas L. fruits Authors: Verma, Shikhar; Rawat, Ajay Kumar Singh; Ramana, Malipeddi Venkata; Dhaneshwar, Suneela Sat, 01 Jun 2019 00:00:00 GMT http://10.9.150.37:8080/dspace//handle/atmiyauni/2264 2019-06-01T00:00:00Z http://10.9.150.37:8080/dspace//handle/atmiyauni/2184 Title: Preparation and Evaluation of Directly Compressible Tablets of Ibuprofen Crystals Authors: Vaghela, Pooja D.; Patel, N.U.; Tank, H.M. Abstract: The goal of present study was to prepare the directly compressible tablets of Ibuprofen crystals prepared by crystallization technique using saccharin sodium as an excipient. The prepared tablets were evaluated for the improvement in drug release of Ibuprofen as compared to the pure drug. The crystal formation of Ibuprofen lead to improve the compressibility and mechanical strength of the drug which can be easily converted to directly compressible tablets. The In-vitro dissolution profile demonstrates 3.96 fold increment in the drug release rate from tablets of Ibuprofen crystals compared to the pure drug after one hour. The characterization was done by Powder X-Ray Diffractometry (pXRD), and Headspace Gas Chromatography (HSGC) Study of Ibuprofen treated crystals illustrates the improvement in manufacturability and pharmacotechnical parameters of the drug. © 2022 iGlobal Research and Publishing Foundation. All rights reserved. Sat, 01 Jan 2022 00:00:00 GMT http://10.9.150.37:8080/dspace//handle/atmiyauni/2184 2022-01-01T00:00:00Z http://10.9.150.37:8080/dspace//handle/atmiyauni/2180 Title: POCl3 catalyzed, one-step, solvent-free synthesis of some novel thieno[2,3-d]pyrimidin-4(3H)-one derivatives as antimicrobial agent Authors: Vadalia, Kantilal R. Abstract: A POCl 3 catalyzed, efficient, one-step and solvent-free synthesis of novel thieno[2,3-d] pyrimidin-4(3H)-one derivatives from 2-amino-4,5-substitutedthiophene-3-carbonitrile has beendeveloped under conventional heating and microwave irradiation. The formation of compounds was confirmed using elemental analysis and spectroscopic techniques like IR, NMR ( 1H and 13C)and mass spectroscopy. Furthermore, they were screened in vitro to study their antimicrobial activ-ity, which shows weak to moderate activity against all tested microorganisms.Ó 2016 King Saud University. Production and hosting by Elsevier B.V. This is an open access article underthe CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Mon, 01 Jan 2018 00:00:00 GMT http://10.9.150.37:8080/dspace//handle/atmiyauni/2180 2018-01-01T00:00:00Z