Please use this identifier to cite or link to this item: http://10.9.150.37:8080/dspace//handle/atmiyauni/1114
Title: Enhanced encapsulation of metoprolol tartrate with carbon nanotubes as adsorbent
Authors: Garala, Kevin
Patel, Jaydeep
Patel, Anjali
Dharamsi, Abhay
Keywords: Multi-walled carbon nanotubes
Central composite design
Ethyl cellulose
In vitro drug release
Microspheres
Issue Date: Sep-2011
Publisher: Applied Nanoscience (Springer)
Citation: Garala, K. ,Patel, J. ,Patel, A. ,Dharamsi, A. (2011). Enhanced encapsulation of metoprolol tartrate with carbon nanotubes as adsorbent. Applied Nanoscience (Springer), ISSN 2190-5509 Appl Nanosci DOI 10.1007/s13204-011-0030-3
Abstract: A highly water-soluble antihypertensive drug, metoprolol tartrate (MT), was selected as a model drug for preparation of multi-walled carbon nanotubes (MWCNTs)- impregnated ethyl cellulose (EC) microspheres. The present investigation was aimed to increase encapsulation efficiency of MT with excellent adsorbent properties of MWCNTs. The unique surface area, stiffness, strength and resilience of MWCNTs have drawn much anticipation as carrier for highly water-soluble drugs. Carbon nanotubes drug adsorbate (MWCNTs:MT)-loaded EC microspheres were further optimized by the central composite design of the experiment. The effects of independent variables (MWCNTs: MT and EC :adsorbate) were evaluated on responses like entrapment efficiency (EE) and t50 (time required for 50% drug release). The optimized batch was compared with drug alone EC microspheres. The results revealed high degree of improvement in encapsulation efficiency for MWCNTs: MT-loaded EC microspheres. In vitro drug release study exhibited complete release form drug alone microspheres within 15 h, while by the same time only 50–60% drug was released for MWCNTs impregnated EC microspheres. The optimized batch was further characterized by various instrumental analyses such as scanning electron microscopy, powder X-ray diffraction and differential scanning calorimetry. The results endorse encapsulation of MWCNTs: MT adsorbate inside the matrix of EC microspheres, which might have resulted in enhanced encapsulation and sustained effect of MT. Hence, MWCNTs can be utilized as novel carriers for extended drug release and enhanced encapsulation of highly watersoluble drug, MT
URI: http://10.9.150.37:8080/dspace//handle/atmiyauni/1114
ISSN: 2190-5509
Appears in Collections:01. Journal Articles

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