Please use this identifier to cite or link to this item: http://10.9.150.37:8080/dspace//handle/atmiyauni/1118
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dc.contributor.authorPatel, Jaydeep-
dc.contributor.authorDhingani, Anjali-
dc.contributor.authorGarala, Kerala-
dc.contributor.authorRaval, Mihir-
dc.contributor.authorSheth, Navin-
dc.date.accessioned2023-05-26T06:00:57Z-
dc.date.available2023-05-26T06:00:57Z-
dc.date.issued2016-
dc.identifier.citationPatel, J. ,Dhingani, A. ,Garala, K. ,Raval, M. ,Sheth, N. (2016). Quality by design approach for oral bioavailability enhancement of Irbesartan by self-nanoemulsifying tablets. Informa healthcare, http://informahealthcare.com/drd ISSN: 1071-7544 (print), 1521-0464 (electronic) Drug Deliv, Early Online: 1–24 ! 2013 Informa Healthcare USA, Inc. DOI: 10.3109/10717544.2013.853709en_US
dc.identifier.issn1521-0464-
dc.identifier.urihttp://10.9.150.37:8080/dspace//handle/atmiyauni/1118-
dc.descriptionWe would like to thank Torrent Research Center for providing gift sample of IRB.en_US
dc.description.abstractThe present investigation was aimed to develop self-nanoemulsifying tablets (SNETs) as novel nanosized solid oral dosage forms for Irbesartan (IRB). In the first part of the investigation, IRB-loaded self-nanoemulsifying drug delivery systems (SNEDDS) were developed using Capryol 90 – Cremophor RH40 – Transcutol P as three component (oil – surfactant – cosurfactant) SNEDDS system. On the basis of ternary phase diagram IRB-loaded SNEDDS were optimized by using Design of Experiments (DoE) and Principal component analysis (PCA) with amount of oil and surfactant: cosurfactant ratio (Km) as factors. The optimized batch of IRBloaded SNEDDS comprised of 31.62% w/w of Capryol 90 as oil phase, 49.90% w/w Cremophor RH40 as surfactant and 18.48% w/w of Transcutol P as cosurfactant exemplified a mean globule size as 23.94 nm. Further, with an aim to provide enhanced patient compliance the optimized batch of liquid SNEDDS was transformed into SNETs by liquisolid compaction technique. Solid state characterization of IRB-loaded liquisolid mixtures revealed a decrease in the magnitude of crystallinity of IRB. The results of in vitro drug release study of optimized batch of IRB-loaded SNET illustrated a remarkable improvement in the dissolution rate as compared to marketed tablets (Avapro 75). The results of in vivo pharmacokinetic study on Wister rats revealed 1.78- fold enhancement in oral bioavailability for IRB-loaded SNETs against marketed tablets. The present study proposed SNEDDS as one of the suitable approach for developing nanosized solid oral dosage forms of poorly water soluble drugs like Irbesartan.en_US
dc.language.isoenen_US
dc.publisherInforma healthcareen_US
dc.subjectIn vivoen_US
dc.subjectirbesartanen_US
dc.subjectliquisolid compactionen_US
dc.subjectprincipal component analysisen_US
dc.subjectself-nanoemulsifying tabletsen_US
dc.titleQuality by design approach for oral bioavailability enhancement of Irbesartan by self-nanoemulsifying tabletsen_US
dc.typeArticleen_US
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