Quality by Design Approach for Development of W/O Type Microemulsion Based Transdermal Systems for Atenolol

Abstract

The objective of the present investigation was to develop microemulsion (ME) based transdermal systems of highly water soluble drug, Atenolol by quality by design technique. Atenolol loaded W/O MEs were optimized using D-optimal design with concentrations of oil, surfactants mixture and water as independent variables which was converted into microemulsion based gel (MBG). The results of in vitro permeation of the optimized batch of Atenolol loaded MBG revealed significant increase in permeability parameters as compared to its convention gel. All these results suggested suitability of W/O type MEs as carriers for transdermal delivery of highly water soluble drug, Atenolol.