Please use this identifier to cite or link to this item: http://10.9.150.37:8080/dspace//handle/atmiyauni/1124
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dc.contributor.authorGarala, Kevin-
dc.contributor.authorPatel, Jaydeep-
dc.contributor.authorPatel, Anjali-
dc.contributor.authorRaval, Mihir-
dc.contributor.authorDharamsi, Abhay-
dc.date.accessioned2023-05-27T03:40:00Z-
dc.date.available2023-05-27T03:40:00Z-
dc.date.issued2012-12-
dc.identifier.citation: Garala K, Patel J, Patel A, Raval M, Dharamsi A. Influence of excipients and processing conditions on the development of agglomerates of racecadotril by crystallo-co-agglomeration. Int J Pharma Investig 2012;2:189-200en_US
dc.identifier.issn2230-973X-
dc.identifier.urihttp://10.9.150.37:8080/dspace//handle/atmiyauni/1124-
dc.descriptionThe authors are grateful to the Gujarat Council on Science and Technology (GUJCOST), Gandhinagar, Gujarat for providing financial assistance in this work (MRP‑2015538). They also express their gratitude to the Evonic Degussa Incorporation, Mumbai, India for providing samples of Eudragit as a giften_US
dc.description.abstractPurpose: The purpose of the present investigation was to improve the flow and mechanical properties of racecadotril by a crystallo‑co‑agglomeration (CCA) technique. Direct tableting is a requirement of pharmaceutical industries. Poor mechanical properties of crystalline drug particles require wet granulation which is uneconomical, laborious, and tedious. Materials and Methods: The objective of this work was to study the influence of various polymers/excipients and processing conditions on the formation of directly compressible agglomerates of the water‑insoluble drug, racecadotril, an antidiarrheal agent. The agglomerates of racecadotril were prepared using dichloromethane (DCM)—water as the crystallization system. DCM acted as a good solvent for racecadotril as well as a bridging liquid for the agglomeration of the crystallized drug and water as the nonsolvent. The prepared agglomerates were tested for micromeritic and mechanical properties. Results: The process yielded ~90 to 96% wt/ wt spherical agglomerates containing racecadotril with the diameter between 299 and 521 μ. A higher rotational speed of crystallization system reduces the size of the agglomerates and disturbs the sphericity. Spherical agglomerates were generated with a uniform dispersion of the crystallized drug. CCA showed excellent flowability and crushing strength. Conclusion: Excipients and processing conditions can play a key role in preparing spherical agglomerates of racecadotril by CCA, an excellent alternative to the wet granulation process to prepare intermediates for direct compression.en_US
dc.language.isoenen_US
dc.publisherInternational Journal of Pharmaceutical Investigationen_US
dc.subjectCrystallo‑co‑agglomerationen_US
dc.subjectcrushing strengthen_US
dc.subjectflowabilityen_US
dc.subjectracecadotrilen_US
dc.titleInfluence of excipients and processing conditions on the development of agglomerates of racecadotril by crystallo‑co‑agglomerationen_US
dc.typeArticleen_US
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