Please use this identifier to cite or link to this item: http://10.9.150.37:8080/dspace//handle/atmiyauni/1128
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dc.contributor.authorEkshinge, Vinit-
dc.contributor.authorGarala, Kevin-
dc.date.accessioned2023-05-27T05:15:08Z-
dc.date.available2023-05-27T05:15:08Z-
dc.date.issued2009-12-
dc.identifier.citationEkshinge, V. ,Garala, K. (2009). Formulation Development of Tramadol Hydrochloride Rapid-disintegrating Tablets Using Simplex Lattice Design . Research Journal of Pharmacy and Technology (RJPT), Research J. Pharm. and Tech.2 (4): Oct.-Dec. 2009, ISSN 0974-3618en_US
dc.identifier.issn0974-3618-
dc.identifier.urihttp://10.9.150.37:8080/dspace//handle/atmiyauni/1128-
dc.descriptionWe are grateful to the Rantus Pharma, Hyderabad, India for the gift sample of Tramadol hydrochloride. We are also grateful to Colorcon Asia Pvt. Ltd., Goa, India for the gift sample of Starch 1500 ®en_US
dc.description.abstractThe effect of a mixture of super disintegrants on the disintegration time and in vitro drug release rate was studied. In this study, an attempt had been made to prepare rapid disintegrating tablets of the drug using different super disintegrants following wet granulation method. The sodium starch glycolate, cross carmellose sodium and pregelatinized starch (Starch 1500 ® ) were used in different concentration according to the simplex lattice design as the super disintegrants. The tablets were evaluated for diameter, thickness, hardness, friability, weight variation, wetting time, percentage of water absorption, disintegration time and in vitro dissolution studies. The disintegration time of all formulation showed less than 75 seconds. The formulation F4 showed low disintegration time that is 14 seconds and the percentage drug release was 97.33 within 10 minutes. The tablets containing equal quantity of Starch 1500 ® and cross carmellose sodium showed lowest disintegration time than other formulation containing Starch 1500 ® , cross carmellose sodium and sodium starch glycolate in various proportions shown in Table-1.en_US
dc.language.isoenen_US
dc.publisherResearch Journal of Pharmacy and Technology (RJPT)en_US
dc.subjectTramadol hydrochlorideen_US
dc.subjectSimplex lattice designen_US
dc.subjectSuper disintegrantsen_US
dc.subjectSpray dryingen_US
dc.titleFormulation Development of Tramadol Hydrochloride Rapid-disintegrating Tablets Using Simplex Lattice Designen_US
dc.typeArticleen_US
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