Physical Penetration Enhancement Through TDDS: A Review

Abstract

The delivery of drugs into systemic circulation via skin has generated lot of interest in recent time. Transdermal drug delivery is now a promising route of drug delivery system. The transdermal drug delivery system has potential advantages of avoiding hepatic first pass metabolism, maintaining constant blood levels for longer period of time, decrease side effects, decrease gastrointestinal effect that occur due to local contact with gastric mucosa and improved compliance. The success of transdermal drug delivery system depends on the ability of the drug to penetrate through the skin in sufficient quantities to achieve desired therapeutic levels. In this article, the most recent editorial briefing on transdermal drug delivery systems by physical enhancement is intended to summarize the progress made in TDDS research and development.