An Emerging Trend in Oral Drug Delivery Technology : Rapid Disintegrating Tablets

Abstract

Recent advances in novel drug delivery system aims to enhance safety and efficacy of drug molecule by formulating a convenient dosage form for administration and to achieve better patient compliance. One such approach is Rapid Disintegrating Tablets (RDT) which are those solid dosage forms when put on tongue, disintegrate or dissolve instantaneously, releasing the drug, within a few seconds without the need of water. RDT can be applicable in difficulty in swallowing (Dysphagia) or chewing solid dosage forms to pediatrics, geriatrics, mentally ill, uncooperative and nauseated patients. RDT is much more advantageous because of ease of administration, enhanced bioavailability, masking the unpleasant taste of drug, etc. Many patented technologies have been developed such as Zydis, Orasolv, Durasolv, WOWTAB, FlashDose, Nanocrystal technology etc. There are many conventional techniques used in manufacturing of RDT such as direct compression, tablet moulding, freeze drying, sublimation etc. RDT can be administered for large number of drugs. The prepared blend can be evaluated for preformulation studies and the prepared tablets are then evaluated for quality control tests. With the help of RDT, the objective of the patient compliance can be satisfactorily achieved.