Solubility Enhancement of Candesartan by Polyamidoamine Dendrimers

Abstract

The present study was aimed for solubility enhancement of candesartan (CND) by dendrimers. The aqueous solubility of CND was measured in the presence of dendrimers in distilled water. The effect of variables (pH condition, concentration of dendrimer, temperature) has been studied via implementation of Box-Behken design of experiment. The order in which the dendrimers increased the solubility at a constant pH condition was G3 > G0. Results revealed that the solubility of CND in the dendrimer solutions was proportional to dendrimer concentration. The influence of dendrimer solution pH on the solubility enhancement of CND suggests that it involves an electrostatic interaction between the carboxyl group of the CND molecule and the amine groups of the dendrimer molecule. The solubility of CND was inversely proportional to the temperature under which the experiment was performed. Polyamidoamine (PAMAM) dendrimers have the potential to significantly enhance the solubility of poor water soluble drugs, CND.