A Review on Solid Self Emulsifying Drug Delivery Systems and Dosage Forms

Abstract

Combinatorial chemistry and high-throughput screening used in drug discovery have resulted in a 70% of new drug candidates shown poor aqueous solubility in recent years which leads to low oral bioavailability. In clinical use, the poor bioavailability of a drug substance might result in limited therapeutic potential, thereby leading to insufficient clinical outcomes. Among the approaches of solubility and bioavailability enhancement, self emulsifying formulations have great potential for hydrophobic drugs. Conventionally SEDDS were prepared in liquid forms which have various disadvantages of liquid dosage forms. Accordingly, solid SEDDS were prepared by various solidification techniques. This article reviews the recent advancement in solid SEDDS with emphasis on solidification technique, solid SEDDS dosage forms, their associated problems and future directions for the research.