| Title: | Influence of eutectic mixture as a multi-component system in the improvement of physicomechanical and pharmacokinetic properties of diacerein |
| Authors: | Patel, Rajeshri Raval, Mihir Pethani, Trupesh Sheth, Navin |
| Keywords: | Diacerein Eutectic Kinetic solubility Cocrystal Physico-mechanical Pharmacokinetic parameters |
| Issue Date: | 2020 |
| Publisher: | Advanced powder Technology, Elsevier |
| Citation: | Rajeshri D. Patel, Mihir K. Raval, Trupesh M. Pethani, Navin R. Sheth, Influence of eutectic mixture as a multi-component system in the improvement of physicomechanical and pharmacokinetic properties of diacerein, Advanced Powder Technology, Volume 31, Issue 4, 2020, Pages 1441-1456, ISSN 0921-8831, https://doi.org/10.1016/j.apt.2020.01.021. |
| Abstract: | A multi-component system of diacerein (DIA) with 2, 4 – dihydroxybenzoic acid (DHA) as coformer at various molar compositions was formulated to simultaneously improve solubility, compressibility and bioavailability of DIA by applying acetone assistant grinding technique. Various evaluation parameters pertaining to measure physicomechanical properties were conducted. Thermal analysis revealed a ‘V’- shaped binary phase diagram along with single melting event as a possibility of eutectic formation between drug and coformer. It was further confirmed PXRD and FT-IR. Equidimensional shape with platy nature of eutectic material was observed in SEM images imparting its better flow and compressibility. Solubility and dissolution study showed 2 and 1.8 folds enhancement respectively compared to pure DIA and control batch. Pharmacokinetic study proved 2.1 times higher bioavailability in case of prepared eutectic compared to DIA along with its stable nature. Hence, the multi-component system can become a potential way for the improvement of material characteristics. |
| Description: | The author gratefully acknowledges Department of Science and Technology (DST), New Delhi, India, for providing DST-INSPIRE Fellowship to carry out this research work. Authors are grateful to Prof. Arvind Bansal, Head, Department of Pharmaceutics, NIPER-Mohali, Prof. Changquan Calvin Sun, Professor, Department of Pharmaceutics, University of Minnesota, USA and Mr. Dnyaneshwar Kale, PhD student, Department of Pharmaceutics, NIPER-Mohali, for their continuous guidance and support throughout the study. |
| URI: | http://10.9.150.37:8080/dspace//handle/atmiyauni/1159 |
| ISSN: | 0921-8831 |
| Appears in Collections: | 01. Journal Articles |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 1041) 94733_Rajeshri Dineshbhai Patel.pdf | 3.4 MB | Adobe PDF | View/Open |
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