Virtual Screening of Potent Compounds for Type 2 Diabetes

Abstract

Type 2 diabetes, the most common type of diabetes, is a disease that occurs when blood glucose, also called blood sugar, is too high. Blood glucose is the main source of energy and comes mainly from the food we eat. Insulin, a hormone made by the pancreas, helps glucose get into the cells to be used for energy. In type 2 diabetes, the body doesn’t make enough insulin or doesn’t use insulin well. Too much glucose then stays in the blood, and not enough reaches the cells. The Protein- Ligand interaction plays a significant role in structural based drug designing. In our research work we have taken the adipokines protein and the commercially available drugs against diabetes. The receptor was docked to the different types of drugs and the energy value obtained as follows Metformin (-8.9kcal), Myo-inositol (-7.9kcal) and berberine (-8.8kcal) using the PyRx docking software. Depending on the energy values we have chosen the best three drugs they are Metformin, Myo-inositol and Berberine.