Synthesis of Substituted 4-(4-((3-Nitro-2-oxo-2H-chromene-4- yl)amino)phenyl)morpholine-3-one Coumarin Derivatives

Abstract

In the large family of heterocyclic chemistry, coumarin and its derivatives have significant role due to their distinct applications, abundant availability in nature and various routes for its synthesis. The main aim of this research is to synthesize 4-(4-amino phenyl)morpholine-3-one substituted coumarin derivatives. Some researchers [1,2] reported several natural and synthetic coumarin derivatives which behaves as antimicrobial agents. Novobiocin and chlorobiocin are important class of anti- microbials compounds containing coumarin ring [3]. Some substituted coumarin derivatives have antibacterial potential and DNA Gyrase inhibitor potential [4]. Di Braccio et al. [5] synthesized coumarin based hydrazine derivative which have antimicrobial property. In the present work, we report the synthesis of 4-(4-((3-nitro-2-oxo-2H-chromen-4-yl)amino)- phenyl)morpholine-3-one by a novel synthetic route by chloro- amine coupling. The interesting chemical and physical properties and the pharmacological effects of aminocoumarin derivatives were the main motivation for starting this research [6]. At first, the 4-amino compound was synthesized as a starting compound for the synthesis of large spectra of new coumarin derivatives [7].