A Concise Review on Characteristics and Analytical Methods of Paroxetine

Abstract

Paroxetine (PAX) is a powerful and selective serotonin reuptake inhibitor (SSRI) with some neuropharmacological properties used mainly for the treatment of anxiety and depression. Due to the first pass degradation, PAX suffers poor bioavailability issues and this limits its clinical application. In context to this, the present review focuses the various formulations related with transdermal liposomes, nano emulsion via olfactory region and brain targeted intranasal in-situ gelling spray for the management of depression. Additionally, we also discuss about the various analytical methods such as HPLC, HPTLC, UV, LC-MS/MS, GC-MS which are reliable and sensitive for the quantification of PAX in different pharmaceutical dosage forms. This concise review presents the survey of physiochemical properties, transdermal as well as intranasal drug delivery systems and analytical methods used for PAX determination, being carried out through scientific journals as well as official compendia.