Design, Synthesis, Characterization and Biological evaluation of (4-(7-chloroquinolin-4-yl) piperazin-1-yl)(substitutedphenyl) methanones as antimicrobial agents

Abstract

A series of (4-(7-chloroquinolin-4-yl)piperazin-1-yl)(substitutedphenyl)methanones were prepared via multistep synthesis which involved acrylation without base, cyclisation, hydrolysis, decarboxylation, electrophilic chlorination reactions and subsequent chloro-amine coupling with various substituted benzoyl chloride derivatives. The structure of the synthesized compounds was established by using elemental analysis, FT-IR, 1H NMR, 13C NMR and Mass spectroscopy. All the novel compounds have been tested on thin layer chromatographic plate for purity and evaluated for their antimicrobial activity against gram positive and gram negative bacteria which demonstrated moderate to good antimicrobial activity