| Title: | Synthesis and in vitro antidiabetic screening of novel dihydropyrimidine derivatives |
| Authors: | Lalpara, J. N. Vachhani, M. D. Hadiyal, S. D. Goswami, S. Dubal, G. G. |
| Keywords: | vitro antidiabetic screening dihydropyrimidine derivatives |
| Issue Date: | 23-Mar-2021 |
| Publisher: | Pleiades Publishing, Ltd. /Russian Journal of Bioorganic Chemistry |
| Citation: | Lalpara, J. N., Vachhani, M. D., Hadiyal, S. D., Goswami, S., & Dubal, G. G. (2021). Synthesis and in vitro antidiabetic screening of novel dihydropyrimidine derivatives. Russian Journal of Organic Chemistry, 57, 241-246 |
| Series/Report no.: | ;57, 241-246 |
| Abstract: | A series of N-substituted-6-methyl-4-{4-[5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl]methoxyphenyl}-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamides have been synthesized by the condensation of newly synthesized {4-[5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl]methoxy}benzaldehyde with variously substituted acetoacetanilides and urea in the presence of ethanol. The synthesized compounds have been characterized by 1H, 13C NMR, IR spectroscopy, and mass spectrometry. All Search Log in synthesized compounds were evaluated for in vitro antidiabetic activity using the α-amylase inhibition assay with the 3,5-dinitrosalicylic acid (DNSA) reagen |
| URI: | http://10.9.150.37:8080/dspace//handle/atmiyauni/1619 |
| Appears in Collections: | 01. Journal Articles |
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| Synthesis and in vitro antidiabetic screening of novel dihydropyrimidine derivatives.pdf | 282.39 kB | Adobe PDF | View/Open |
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