Trimethylsilyl chloride catalyzed synthesis of fluoro substituted tetrahydropyrimidines: Molecular docking and antidiabetic studies

Abstract

A novel series of tetrahydropyrimidine derivatives containing azepino indole and aryl substitution was achieved by a multicomponent synthetic approach using Biginelli condensation. Various catalysts were employed in the reactions for yield increment but trimethylsilyl chloride gave the highest yield. Moreover, all synthesized molecules were checked for in vitro antidiabetic poten- tial. In addition, molecular docking of these synthesized molecules was studied using barley alpha-amylase isozyme 1 (amy1) (1RPK). The result revealed that compounds 4a and 4c have a good inhibitory potential