New 1,3,4-Oxadiazole based Schiff base Derivatives: Synthesis, Characterization and Antibacterial Activity Along With in Silico Studies

Abstract

A series of novel 1,3,4-oxadiazole based Schiff base derivatives were designed and synthesized using the efficient strategy with excellent yields. Synthesized molecules evaluated in vitro antibacterial studies in contradiction of microorganisms, namely Escherichia coli, Klebsiella pneumoniae, Bacillus subtilis, and Bacillus megaterium. The bioassay result revealed that most of tested compounds good to moderate inhibition against microorganisms. Some among them show excellent inhibitory effects towards the Gram-positive and Gram-negative bacteria. Besides, the drug-likeness, lipophilicity and cytotoxicity