| Title: | Stability Indicating RP-UPLC Method for the Quantitative Determination of Degradation Impurities of Benidipine Hydrochloride & Metoprolol Succinate in Combined Dosage Form |
| Authors: | Shah, Pranavkumar Hadiyal, Sanjay Lalpara, Jaydeep Dubal, Gaurang Dhaduk, Bhavin |
| Keywords: | RP-UPLC Method Quantitative Determination Degradation Impurities Benidipine Hydrochloride Metoprolol Succinate Combined Dosage Stability |
| Issue Date: | 2024 |
| Publisher: | Springer / Pharmaceutical Chemistry Journal |
| Citation: | Shah, P., Hadiyal, S., Lalpara, J., Dubal, G., & Dhaduk, B. (2024). Stability Indicating RP-UPLC Method for the Quantitative Determination of Degradation Impurities of Benidipine Hydrochloride & Metoprolol Succinate in Combined Dosage Form. Pharmaceutical Chemistry Journal, 57(10), 1674-1682. |
| Series/Report no.: | ;57(10), 1674-1682 |
| Abstract: | A suitable RP-UPLC method for the quantitative analysis of degradation impurities of Benidipine hydrochloride & Metoprolol succinate is reported. The method was validated for specicity, linearity, range, accuracy, precision, sensitivity (LOQ and LOD), and robustness. The method shows excellent linearity with linear regression (r > 0.9950) within concentration range (0.5 to 3.0 μg/mL). LOD values were 0.14, 0.16 and, 0.15 and LOQ values were 0.42, 0.49 and 0.45 μg/mL for MET impurity-B & O and BEN impurity-2, respectively. The proposed method could be applied to routine quality control analysis |
| URI: | http://10.9.150.37:8080/dspace//handle/atmiyauni/1671 |
| Appears in Collections: | 01. Journal Articles |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| Stability Indicating RP-UPLC Method for the Quantitative Determination of Degradation Impurities of Benidipine Hydrochloride & Metoprolol Succinate in Combined Dosage Form.pdf | 209.83 kB | Adobe PDF | View/Open |
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