Anti-cancer Investigation of Newly Derived Alicyclic ring and Morpholine Supported Hybrid Molecules by Industrially viable Route

Abstract

In an attempt to design and synthesize a new class of anticancer molecules, we have reported coupling of aryl aldehyde, p-toluidine and morpholine based isocyanide with cyclopropane carboxylic acid to generate a small library of 08 compounds (5a-5h) by ugi multicomponent reaction in a single step manner. Structures of the newly synthesized compounds were recognized on the basis of spectral data i.e. 1H NMR, 13C NMR, IR and Mass. These compounds were screened for their anticancer activity against nine basic panels as well as NCI-60 cell-lines. In vitro anticancer studies revealed that the compound 5ashowed maximum potency against HCT-116 in colon cancer cell lines with GI50 values 46.27 µg/ml.