“Click Chemistry” Inspired Synthesis and Antimicrobial Evaluation of 1,2,4-triazolo[4,3-a]pyridine linked 1,4-disubstituted 1,2,3-triazole Derivatives with Amide Functionalities

Abstract

In an attempt to rationalize the search for new potential antimicrobial agents, a new series of 1,2,4-triazolo[4,3-a] pyridine linked 1,4-disubstituted 1,2,3-triazoleswith amide linkage has been synthesized by the cyclization of 1,2,4-triazolo[4,3-a]pyridine-based alkynes and 2-azido N-phenylacetamide in the presence of CuSO4 as catalyst through ‘‘Click Chemistry” approach. The newly synthesized scaffolds have been evaluated for their antimicrobial potential using eight microbial strains such as Escherichia coli, Pseudomonas aeruginosa, Enterobacter aerogenes, Bacillus megaterium, Staphylococcus aureus, Bacillus subtilis, Aspergillus Niger, and Aspergillus flavus. Results revealed that all synthesized scaffolds displayed superior activities than the standard drugs against various microbial strains. The synthesized compounds showed potential antimicrobial activity against Gram-positive, Gram-negative bacteria, and fungi