Please use this identifier to cite or link to this item: http://10.9.150.37:8080/dspace//handle/atmiyauni/2029
Full metadata record
DC FieldValueLanguage
dc.date.accessioned2024-11-25T10:32:51Z-
dc.date.available2024-11-25T10:32:51Z-
dc.date.issued2018-
dc.identifier.citationLunagariya, M. V., Thakor, K. P., Varma, R. R., Waghela, B. N., Pathak, C., & Patel, M. N. (2018). Synthesis, characterization and biological application of 5-quinoline 1, 3, 5-trisubstituted pyrazole based platinum (ii) complexes. MedChemComm, 9(2), 282-298.en_US
dc.identifier.urihttp://10.9.150.37:8080/dspace//handle/atmiyauni/2029-
dc.description.abstractSquare planar mononuclear platinum(II) complexes were synthesized in the presence of neutral bidentate heterocyclic (5-quinoline 1,3,5-tri-substituted pyrazole scaffold) ligands and K2PtCl4 salt. The synthesized compounds were characterized by micro-elemental analysis, FT-IR, UV-vis, 1H NMR, 13C NMR, TGA, mass spectrometry and molar conductivity. Their biological activities were investigated by in vitro brine shrimp lethality bioassay, in vitro antimicrobial study against five different pathogens, in vivo cellular level cytotoxicity against Schizosaccharomyces pombe cells, and in vitro anti-proliferation assay. The binding constant Ksv, Kb, Ka values of the complexes were determined by DNA interaction studies. The gel electrophoresis assay was carried out to examine the effect of the complexes on the DNA nuclease of pUC19 plasmid DNA. The docking energies of the ligands (L1–L5) and complexes (I–V) were observed in the range of −265.14 to −284.33 kJ mol−1. The synthesized Pt(II) complexes (I–V) were screened against the MCF-7 (human breast adenocarcinoma) and HCT-116 (human colon carcinoma) cancer cell lines.en_US
dc.language.isoenen_US
dc.publisherMedChemCommen_US
dc.subjectSynthesisen_US
dc.subjectcharacterization and biologicalen_US
dc.subjecttrisubstituteden_US
dc.subjectpyrazole baseden_US
dc.titleSynthesis, characterization and biological application of 5-quinoline 1,3,5-trisubstituted pyrazole based platinumIJII) complexesen_US
dc.typeArticleen_US
Appears in Collections:01. Journal Articles

Files in This Item:
File Description SizeFormat 
Synthesis, characterization and crystallographic analysis of.pdf362.38 kBAdobe PDFView/Open
Show simple item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.