Please use this identifier to cite or link to this item: http://10.9.150.37:8080/dspace//handle/atmiyauni/2039
Title: Insights of Endocytosis Signaling in Health and Disease
Authors: Pathak, C.,
Vaidya, F. U
Waghela, B. N.,
Jaiswara, P. K
Gupta, V. K
Kumar, A
Ranjan, K.
Keywords: Endocytosis
Signaling
Issue Date: 2023
Publisher: journal of molecular sciences
Citation: Pathak, C., Vaidya, F. U., Waghela, B. N., Jaiswara, P. K., Gupta, V. K., Kumar, A., ... & Ranjan, K. (2023). Insights of endocytosis signaling in health and disease. International journal of molecular sciences, 24(3), 2971.
Abstract: Endocytosis in mammalian cells is a fundamental cellular machinery that regulates vital physiological processes, such as the absorption of metabolites, release of neurotransmitters, uptake of hormone cellular defense, and delivery of biomolecules across the plasma membrane. A remarkable characteristic of the endocytic machinery is the sequential assembly of the complex proteins at the plasma membrane, followed by internalization and fusion of various biomolecules to different cellular compartments. In all eukaryotic cells, functional characterization of endocytic pathways is based on dynamics of the protein complex and signal transduction modules. To coordinate the assembly and functions of the numerous parts of the endocytic machinery, the endocytic proteins interact significantly within and between the modules. Clathrin-dependent and -independent endocytosis, caveolar pathway, and receptor mediated endocytosis have been attributed to a greater variety of physiological and pathophysiological roles such as, autophagy, metabolism, cell division, apoptosis, cellular defense, and intestinal permeabilization. Notably, any defect or alteration in the endocytic machinery results in the development of pathological consequences associated with human diseases such as cancer, cardiovascular diseases, neurological diseases, and inflammatory diseases. In this review, an in-depth endeavor has been made to illustrate the process of endocytosis, and associated mechanisms describing pathological manifestation associated with dysregulated endocytosis machinery.
URI: http://10.9.150.37:8080/dspace//handle/atmiyauni/2039
Appears in Collections:01. Journal Articles

Files in This Item:
File Description SizeFormat 
Insights of Endocytosis Signaling in Health and Disease.pdf1.75 MBAdobe PDFView/Open
Show full item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.