Sulpha Drugs based Heterochelates: Synthesis, Spectroscopic, Thermal and In-vitro Biological Studies

Abstract

In the current study, dapsone and different 4-Acyl pyrazolone derivatives were used to synthesise various Cu(II) and Ni(II) based heterochelates. Elemental analysis, 1H NMR, IR, and mass spectroscopy were utilized to check the structure of the tetra dentate DPL1 to DPL5 ligands, and FAB mass spectroscopy as well as temperature investigations (TGA/DTG and DSC) were utilized to approve the structure of the Cu(II) and Ni(II) heterochelates. All the synthesized compounds were examined for their in-vitro biological study against two Gram +ve (Bacillus cereus, Bacillus megaterium) and two Gram-ve (Escherichia coli, Enterobacter aerogene) microorganisms as well as their MIC against two Gramme +ve (Bacillus subtilis, Staphylococcus aureus) and two Gram-ve (Escherichia coli, Serratia marcescens) microorganisms. The outcomes demonstrated the tremendous promise and importance of novel bis-pyrazolone heterochelates based on dapsone for further study.