POCl3 catalyzed, one-step, solvent-free synthesis of some novel thieno[2,3-d]pyrimidin-4(3H)-one derivatives as antimicrobial agent

Abstract

A POCl 3 catalyzed, efficient, one-step and solvent-free synthesis of novel thieno[2,3-d] pyrimidin-4(3H)-one derivatives from 2-amino-4,5-substitutedthiophene-3-carbonitrile has beendeveloped under conventional heating and microwave irradiation. The formation of compounds was confirmed using elemental analysis and spectroscopic techniques like IR, NMR ( 1H and 13C)and mass spectroscopy. Furthermore, they were screened in vitro to study their antimicrobial activ-ity, which shows weak to moderate activity against all tested microorganisms.Ó 2016 King Saud University. Production and hosting by Elsevier B.V. This is an open access article underthe CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).