Development and Evaluation of Ketoconazole Serum

Abstract

This work is an outlines of development and evaluation of an anti-fungal ketoconazole serum. A skin serum is a concentrated skincare product formulated with high levels of active ingredients designed to address specific skin concerns. Fungal infections pose a significant health threat worldwide, so it requires a good or effective dosage form of antifungal agent. Ketoconazole broad-spectrum anti-fungal agent in this study we develop and evaluate ketoconazole serum for topical use & topical application. Ketoconazole main effect is anti-fungal, dermatitis and anti-dandruff but on skin formulation mainly effect is anti-fungal and concentration of ketoconazole are mainly use is a 1%, 1.5% and 2%. As a formulation, serum contains ketoconazole with Rose oil and we use a minimum excipients an achieve an anti-fungal action for human skin. To formulate a serum we use excipients like a moisturizing agent, humectant, emulsifier, preservatives and stabilizing agents. Then the variety of factors we need to check like stability and compatibility. We use a methanol and rose oil that improve solubility of drug ketoconazole and also they have an individual anti-fungal and anti-microbial activity. Tween 20 used to improve solubility of ketoconazole and also acting as an emulsifier. Glycerine is use as a humectant or moisturizing agent and xanthan gum use as stabilizing agent. To preparation method of serum use as Mechanical starrer 700-800rpm for 15 min. For the stability concern sequence of addition of API & excipient is important application. Evaluation parameter like a pH, general appearance, spread-ability, wash-ability, Absorption time, viscosity, Anti-microbial activity at a laboratory scale and all evaluation parameter was in standard limit.