Medicated Ghrita Based Herbal Suppositories For The Treatment of Anorectal Disorder

Abstract

This study presents the development and evaluation of polyherbal suppositories containing Jatyadi Ghrita (JG) for the treatment of anorectal disorders like fissures, fistulas, and hemorrhoids. JG is a renowned Ayurvedic formulation with wound-healing properties. The suppositories were prepared by the fusion or melt process, incorporating JG along with natural beeswax as the base, and oils like Kasisadi oil, neem oil, and tea tree oil for their therapeutic benefits. Various trials were conducted to optimize the composition, and the final formulation consisted of JG (70%), beeswax (10%), Kasisadi oil (10%), neem oil (5%), and tea tree oil (5%). The optimized suppositories were evaluated for parameters like visual examination, disintegration time (28 minutes), liquefaction time (8 minutes), melting range (37.5 ± 2°C), and mechanical strength (2.26 kg). The results complied with the standard values specified in the Indian Ayurvedic Pharmacopoeia, indicating their suitability for rectal administration. The developed JG suppositories demonstrated desirable physicochemical properties and could potentially serve as a practical, non-invasive treatment option for anorectal disorders, pending further clinical studies.