Synthesis Characterization and Biological Evaluation of Some Novel Schiff’s Base and Amine Derivatives of Pyrazole

Abstract

A novel series of Schiff’s base and amine derivatives of 5-amino-3-(methylthio)-N-(4-(3-oxomorpholino)phenyl)-1H-pyrazole-4-carboxamide have been synthesized by using different aromatic aldehydes and followed by reduction of Schiff’s base with sodium borohydride in very good yield. The structures of the synthesized compounds have been characterized by using IR, 1H NMR and Mass spectroscopy. All the prepared new NCEs were screened for anti-microbial activity and anti-fungal activity.