Synthesis and Biological Screening of N-(4-(6- Amino-5-cyano-4-aryl-pyridin-2-yl) phenyl) cyclopropane Carboxamide

Abstract

Abstract: Cyanopyridine derivatives shows good biological and therapeutic activities and exhibit wide range of applications in the field of pharmaceutical and agriculture. Cyanopyridine derivatives like some new N-(4-(6-Amino-5-cyano-4-aryl-pyridin-2- yl)phenyl)cyclopropane carboxamide of type (2a-l) have been prepared by the condensation of such new chalcone derivatives N- (4-(3-Aryl- acryloyl)phenyl)cyclopropane carboxamide of type (1a-l) with Malononitrile in presence of Ammonium acetate. All the prepared compounds were characterized by their spectral (I.R., 1H NMR. & Mass) data and screened for their antimicrobial activities.