Synthesis and biological evaluation of some 4-hydroxy-3-[3-(substituted phenyl)- prop-2-enoyl]-2h-chromen-2-ones

Abstract

Due to the presence of unsaturated ketone chalcone derivatives from nature or synthetic provenance display manifold pharmacological activities. The present work deals with the unfolding of the biological potency, if any, of some of the newly synthesized benzalacetophenones. Out of the 20 homologues synthesized the 6 were found active against the bacterial strain and 3 were active against fungal strains. The structures of the compounds were supported by UV, IR, NMR, Mass spectroscopy and elemental analysis.