Title: | Synthesis of Some New 2-Amino/Methoxy-4-(3- Methoxy-4-((3-Methyl-4-(2,2,2-Trifluoroethoxy) Pyridin-2-Yl) Methoxy) Phenyl)-6- Arylnicotinonitrile Derivative and Its Biological Activity |
Authors: | Patel, Piyush A. Kakadiya, Sandip P. Bhadani, Vijay N. Purohit, Heta D. Bhatt, Parth V. Purohit, Dipak M. |
Keywords: | 2-Amino-3-cyanopyridine, 2-Methoy-3-cyanopyridine, Antimicrobial activity. |
Issue Date: | 1-Nov-2017 |
Publisher: | International Journal for Research in Applied Science & Engineering Technology |
Citation: | Patel, P. A., Bhadani, V. N., Purohit, H. D., Bhatt, P. V., & Purohit, D. M. (2015). Synthesis of Some new2-Amino/Methoxy-4-(3-methoxy-4-((3-methyl-4-(2, 2, 2-trifluoroethoxy) pyridin-2-yl) methoxy) phenyl)-6-arylnicotinonitrileDerivative and its biological activity. Chemistry & Biology Interface, 5(6). |
Abstract: | A series of novel 2-Amino-3-cyanopyridine derivatives 2a-l and 2-Methoy-3-cyanopyridine derivatives 3a-l have been synthesized as potential antibacterial agents. The 2-Amino-3-cyanopyridine derivatives 2a-l have been synthesized by reaction of various Chalcones 1a-l with malononitrile and ammonium acetate in Ethanol. The 2-Methoy-3-cyanopyridine 3a-l were prepared by the reaction of Chalcone with malononitrile and sodium methoxide in Methanol. The structures of the new compounds were established on the basis of 1H-NMR, Mass, IR and elemental analysis data. All the newly synthesized compounds were screened for their antibacterial activity against E. coli, S. thyphi (Gram-negative bacteria), S. aureus, M. luteus (Gram-positive bacteria) and antifungal activity against Candida albicans (Fungi). |
URI: | https://www.ijraset.com/archive-detail.php?AID=64 http://10.9.150.37:8080/dspace//handle/atmiyauni/693 |
ISSN: | 2321-9653 |
Appears in Collections: | 01. Journal Articles |
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VSC_CHE_FJA_29.pdf | 562.45 kB | Adobe PDF | View/Open |
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