Synthesis of Some New 2-Amino/Methoxy-4-(3- Methoxy-4-((3-Methyl-4-(2,2,2-Trifluoroethoxy) Pyridin-2-Yl) Methoxy) Phenyl)-6- Arylnicotinonitrile Derivative and Its Biological Activity

Abstract

A series of novel 2-Amino-3-cyanopyridine derivatives 2a-l and 2-Methoy-3-cyanopyridine derivatives 3a-l have been synthesized as potential antibacterial agents. The 2-Amino-3-cyanopyridine derivatives 2a-l have been synthesized by reaction of various Chalcones 1a-l with malononitrile and ammonium acetate in Ethanol. The 2-Methoy-3-cyanopyridine 3a-l were prepared by the reaction of Chalcone with malononitrile and sodium methoxide in Methanol. The structures of the new compounds were established on the basis of 1H-NMR, Mass, IR and elemental analysis data. All the newly synthesized compounds were screened for their antibacterial activity against E. coli, S. thyphi (Gram-negative bacteria), S. aureus, M. luteus (Gram-positive bacteria) and antifungal activity against Candida albicans (Fungi).