An Efficient and Facile Synthesis of 4-Aryl-2- Hydroxy-6-{[(3′-Difluoromethoxy)-5′-(3″-Methyl)- 4″-(2‴, 2‴, 2‴-Trifluoroethoxy) Pyridin-2″-Yl] Methoxyphenyl}-1-6-Dihy Dropyrimidines.

Abstract

Pyrimidine (1:3 Diazine) derivatives showed good biological and therapeutic activities, with a view of getting to synthesized 4-aryl-2-hydroxy-6-{[(3′-Difluoromethoxy)-5′-(3″-methyl)-4″-(2‴,2‴,2‴-trifluoroethoxy)pyridin-2″-yl]methoxyphenyl}-1-6-dihydropyrimidines (3a-3k) by the cyclo condensation of (E)-3-{[(3′-Difluoromethoxy)-5′-(3″-methyl)-4″- (2‴,2‴,2‴-trifluoroethoxy)pyridine-2-yl]methoxyphenyl}-1-aryl-prop-2-ene-1-ones with urea in presence of alcoholic KOH. All Synthesized compounds characterized by TLC, IR, 1HNMR, Mass spectra and Physical constants. All the synthesized compounds screened for their antimicrobial activity against Gram +ve bacteria (B.mega,B.Subtillis), Gram -vebacteria(E.coli,P.fluorescens) and fungi (A.awamori).