Synthesis And Biological Screening Of 2-Amino-6-Aryl- 4-{[(3′-Difluoromethoxy)-5′-(3″-Methyl)-4″-(2‴,2‴,2‴- Trifluoroethoxy)Pyridin-2″-Yl]Methoxyphenyl}- Nicotinonitriles

Abstract

Cyanopyridine derivatives shows good biological and therapeutic activities, With a view of getting to synthesized 2-Amino-6-aryl-4- {[(3′-difluoromethoxy)-5′-(3′′-methyl)-4′′-(2′′′,2′′′,2′′′-trifluoroethoxy) pyridin-2′′-yl]methoxyphenyl}-nicotinonitriles (3a-3k) by the condensation of (E)-3-{[(3′-difluoromethoxy)-5′-(3″-methyl)-4″- (2‴,2‴,2‴-trifluoroethoxy) pyridine-2-yl] methoxy phenyl}-1-aryl-prop- 2-ene-1-ones with malononitrile in presence of ammonium acetate. All Synthesized compounds characterized by TLC, IR, 1HNMR, Mass spectra and Physical constants. All the synthesized compounds screened for their antimicrobial activity against Gram +ve bacteria (B.mega, B.Subtillis) Gram -ve bacteria (E.coli, P.fluorescens) and fungi (A.awamori).