| Title: | Synthesis Of Novel Substituted 2h-Thiazolo [3,2-A] Pyrimidines Using Water As Green Solvent And Their Antimicrobial Evaluation |
| Authors: | Audichya, Vipul B. Savant, Mahesh M. Naliapara, Yogesh T. |
| Keywords: | Thiazolo[3,2-a]pyrimidine, Pyrimidine, Alkylation Antimicrobial evaluation. |
| Issue Date: | 8-Feb-2017 |
| Publisher: | World Journal of Pharmacy and Pharmaceutical Sciences |
| Citation: | Audichya, V. B., Savant, M. M., & Naliapara, Y. T. (2017). SYNTHESIS OF NOVEL SUBSTITUTED 2H-THIAZOLO [3, 2-a] PYRIMIDINES USING WATER AS GREEN SOLVENT AND THEIR ANTIMICROBIAL EVALUATION. World Journal of Pharmacy and Pharmaceutical Sciences, 6(3), 775-786. |
| Abstract: | A novel series of N,5-bis(4-fluorophenyl)-3,5-dihydro-7-isopropyl-2H-thiazolo[3,2-a]pyrimidine -6-carboxamide has been prepared by reaction of N,4-bis(4-fluorophenyl)-1,2,3,4-tetrahydro-6-isopropyl-2-thioxopyrimidine-5-carboxamide with dibromoethane using basic catalysts TEA/ K2CO3, in the presence of TBAB/TEAB in water. We found water as an efficient and green solvent for the synthesis of novel thiazolo [3,2-a] pyrimidine scaffolds in good yields for biological interest. Among all compounds, 8c, 8g, 8i, 8l and 8o shows good antimicrobial activity against bacterial strain compare to ciprofloxacin. |
| URI: | https://www.wjpps.com/Wjpps_controller/abstract_id/6738 http://10.9.150.37:8080/dspace//handle/atmiyauni/710 |
| ISSN: | 2278–4357 |
| Appears in Collections: | 01. Journal Articles |
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|---|---|---|---|---|
| VSC_IC_FJA_9.pdf | 457.39 kB | Adobe PDF | View/Open |
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