Design, synthesis, characterization and antimicrobial screening of 4-((4-((6-methylbenzo[d]thiazol-2-yl)amino)-6- (phenylamino)-1,3,5-triazin-2-yl)oxy)-2H-chromen-2- one derivatives

Abstract

We have described an easy and conventional method for the synthesis of novel 4-hydroxy coumarin, 2-amino-6-methyl benzothiazole and arylamino bearing 1,3,5-triazine derivatives with good to high yields. The reaction of cyanuric chlorides with coumarin afforded the intermediates under basic condition. Followed by reaction with benzothiazole derivative and different amines under developed reaction conditions yielded the desired trisubstituted 1,3,5-triazines 6a-n. Among the synthesized compounds, some compounds were screened against Gram positive and Gram negative bacteria and fungi and examined zone of inhibition. Out of them, compound 6h has found significant against four microorganisms up to the inhibition of 1.75 to 5.75 mm.