| Title: | Facile synthesis of (E)-5-styrylpyrimidines via wittig reaction using sodium tripolyphosphate in water |
| Authors: | Patel, Anilkumar S. Gandhi, Sahaj A. Modh, Rajesh D. Patel, Urmila H. Naliapara, Yogesh T. Kapuriya, Naval P. |
| Keywords: | Wittig reaction, (E)-5-styrylpyrimidines sodium tripolyphosphate water-mediated green chemistry |
| Issue Date: | 2021 |
| Publisher: | Letters in Organic Chemistry, Bentham Science Publishers |
| Citation: | Patel, A. S., Gandhi, S. A., Modh, R. D., Patel, U. H., Naliapara, Y. T., & Kapuriya, N. P. (2021). Facile Synthesis of (E)-5-Styrylpyrimidines via Wittig Reaction Using Sodium Tripolyphosphate in Water. Letters in Organic Chemistry, 18(8), 634-639. |
| Abstract: | An inexpensive and eco-friendly Wittig olefination protocol has been developed to prepare novel (E)-5-styrylpyrimidines. The reaction of pyrimidine phosphonium ylide with different aryl/heteroaryl aldehydes underwent smoothly in the presence of sodium tripolyphosphate (STPP) in aqueous condition giving (E)-5-styrylpyrimidines (10a-t) in very high yields (77-96 %). |
| Description: | We are thankful to the Department of Chemistry, Shree M. & N. Virani Science College (Autonomous) Rajkot, Bhakta Kavi Narsinh Mehta University, Junagadh, and Saurashtra University, Rajkot for providing necessary research and literature search facilities. The authors are also thankful to the “National Facility for Drug Discovery through NCE’s Development and Instrumentation Support to Small Manufacturing Pharma Enterprises” (NFDD) program under DPRS jointly funded by the Department of Science and Technology (DST) for spectral analysis. |
| URI: | http://10.9.150.37:8080/dspace//handle/atmiyauni/862 |
| ISSN: | 1875-6255 |
| Appears in Collections: | 01. Journal Articles |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 205) 72869_Anilkumar Sundarjibhai Patel.pdf | 1.38 MB | Adobe PDF | View/Open |
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