| Title: | Development of Nitromethane catalyzed C-H activation for the preparation of chromeno[3,4-d]imidazol-4-ones as hybrid scaffolds |
| Authors: | Jain, Vicky Bijani, Sabera Ambasana, Pratik Bhoya, Umed Shah, Anamik |
| Keywords: | hybrid molecules coumarin tandem cyclization nitromethane imidazole |
| Issue Date: | 2015 |
| Publisher: | Chemistry & Biology Interface |
| Citation: | Jain, V., Bijani, S., Ambasana, P., Bhoya, U., & Shah, A. (2015). Development of Nitromethane catalyzed CH activation for the preparation of chromeno [3, 4-d] imidazol-4-ones as hybrid scaffolds. Chemistry & Biology Interface, 5(6). |
| Abstract: | Herein we report a tandem cyclization protocol towards hitherto unprepared hybrid scaffolds of coumarin and imidazole core. The synthetic methodology initiates with linking of aromatic amines with coumarin at 4-position, followed by tandem cyclization with the help of nitromethane leading to the synthesis of title compounds in high to excellent yields (80-97%). Detailed characterization including 1 H NMR, 13C NMR and HRMS for all newly synthesized compounds has been reported |
| Description: | The authors are thankful to funding agencies UGC (SAP) DRS-II & DSA-I, GOI, New Delhi, DST (FIST-II), GOI, New Delhi, National Facility for Drug Discovery Centre (DST-DPRP) and Centre of Excellence in Drug Discoveryd funded by Industries Commissionerate Gujarat (India). The authors are also thankful to Professor and Head at Department of Chemistry, Saurashtra University, Rajkot for providing facilities. |
| URI: | http://10.9.150.37:8080/dspace//handle/atmiyauni/863 |
| ISSN: | 2249-4820 |
| Appears in Collections: | 01. Journal Articles |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 217) 68373_Pratik Anilbhai Ambasana.pdf | 1.43 MB | Adobe PDF | View/Open |
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