Cu(II) heterochelates: Synthesis, spectroscopic, thermal and in-vitro biological studies

Abstract

Novel organic based compound 4-Acyl pyrazolone derivatives and their thermal and biological activities were investigated. A new series of Bis-pyrazolone containing ligand and their Cu(II) based heterochelate were synthesis by various acyl chloride. The structure of bis-pyrazolone ligands were confirmed by 1H NMR, IR, Elemental analysis and their heterochelates were confirmed by thermal studies (TGA and DSC) and FAB Mass spectroscopy. All the synthesized compounds were screened for their In-Vitro biological study against two Gram +ve (Bacillus cereus, Bacillus megaterium) and two Gram-ve (E. coli, E .aerogen) microorganism. The results confirmed that novel bis-pyrazolone based heterochelates have a great potential and significant for further investigation.