Please use this identifier to cite or link to this item: http://10.9.150.37:8080/dspace//handle/atmiyauni/914
Full metadata record
DC FieldValueLanguage
dc.contributor.authorParmar, Minaxi-
dc.contributor.authorPandhi, Neepa-
dc.contributor.authorPatel, Prabhudas-
dc.contributor.authorGupta, Vijaykumar-
dc.date.accessioned2023-05-10T05:49:46Z-
dc.date.available2023-05-10T05:49:46Z-
dc.date.issued2017-11-
dc.identifier.citationParmar, M. M., Pandhi, N., Patel, D., & Gupta, D. (2017). Prevalence of High-Risk Human Papilloma Virus (HR-HPV) As a Risk Factor in HNSCC Patients of Saurashtra Region of Gujarat. Int J Health Science Res, 11(7), 63-69.en_US
dc.identifier.issn2249-9571-
dc.identifier.urihttp://10.9.150.37:8080/dspace//handle/atmiyauni/914-
dc.descriptionWe gratefully acknowledge the funding agency, the University Grant Commission (UGC) of the Government of India, for providing financial support in the form of minor research project. We thank Head and Neck cancer patients who participated in the study for their co-operation. We are grateful to Dr. Geet Gupta and Dr. Khyati Babaria from department of pathology and Dr. Nirav Modi from department of Head and Neck Surgery at Smt V.R. Desai Cancer Research centre, Rajkot and their hospital staff for providing the HNSCC tumor samples.en_US
dc.description.abstractBackground: In India HNSCC comprises the largest group of malignancies with an incidence rate as high as 30-40%.The present study was carried out to determine the prevalence of high-risk human papilloma virus (HR-HPV) as a risk factor in HNSCC patients of Saurashtra region of Gujarat. Method: Newly diagnosed 200 HNSCC patients were selected for the study. Sociodemographic and clinical data were obtained through questionnaire. Detection of HPV-DNA was done from cancer tissues by PCR amplification method using GP5+/GP6+ primers, E6 and E7 primers for HPV 16 and HPV 18 genotypes. Result: The prevalence of HPV high-risk (HR) types was 2% in HNSCC cancer cases. HPV 16 genotype was identified while HPV 18 was absent in all the patients. The risk factor of HPV-HR included younger age (<55 years) and early age at first sexual intercourse. The other risk factors like tobacco and alcohol were absent in these patients. The site of cancer was found to be base of tongue and tonsil. Conclusion: The specific characteristics found in HPV positive HNSCC cases are in accord with distinctive characteristics of HPV positive HNSCC found worldwide. We can conclude that HR-HPV infection may be responsible for HPV-positive HNSCC. However, the prevalence of HPV among HNSCC is negligible which indicates that HPV is not an influential risk factor for oral cancer in this region.en_US
dc.description.sponsorshipUGC,Indiaen_US
dc.language.isoenen_US
dc.publisherInternational Journal of Health Sciences & Researchen_US
dc.subjectHR-HPVen_US
dc.subjectHead and Neck squamous cell carcinomaen_US
dc.subjectPCRen_US
dc.titlePrevalence of High-Risk Human Papilloma Virus (HR-HPV) as a risk factor in HNSCC patients of Saurashtra region of Gujaraten_US
dc.typeArticleen_US
Appears in Collections:01. Journal Articles

Files in This Item:
File Description SizeFormat 
455) 16389_Minaxi Meghjibhai Parmar.pdf409.11 kBAdobe PDFView/Open
Show simple item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.